Protein Details: Aquaporin Z 2

Protein ID

ICDB_Pro_1322

Protein Name

Aquaporin Z 2

Gene Name

aqpZ2; Atu5361; AGR_pAT_521

Organism

Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58))

Length

228 amino acids

AlphaFoldDB

AF-Q8UJW4-F1-model_v4.pdb

Function

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.

Sequence

MGRKLLAEFFGTFWLVFGGCGSAVFAAAFPELGIGFTGVALAFGLTVLTMAYAVGGISGGHFNPAVSVGLTVAGRFPASSLVPYVIAQVAGAIVAAAALYVIATGKAGIDLGGFASNGYGEHSPGGYSLVSALLIEIILTAFFLIVILGSTHGRVPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGQALFVGGWALQQLWLFWLAPIVGGAAGAVIWKLFGEKD

PDB Structures

3LLQ

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 20: "Involved in tetramerization or stability of the tetramer"; SITE 43: "Selectivity filter"; SITE 172: "Selectivity filter"; SITE 181: "Selectivity filter"; SITE 187: "Selectivity filter"

Disease

Location

DOI ID

10.1126/science.1066804; 10.1126/science.1066803

RefSeq

NP_396294.1; WP_010974613.1